Transcription of the three HMG-CoA reductase genes of Mucor circinelloides
نویسندگان
چکیده
منابع مشابه
Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP.
The acyl-CoA binding protein (ACBP) is an ubiquitary expressed multi-functional protein which regulates basic cellular functions such as fatty acid and steroid metabolism. Since ACBP is described to interact with the transcription factor hepatocyte nuclear factor 4 alpha (HNF-4alpha), we investigated the role of human ACBP on transcriptional regulation of the putative HNF-4alpha target gene HMG...
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Pleiotropic effects are now described for the 3-hydroxy-3methylglutaryl-coenzyme A reductase inhibitors (or statins) that might have utility in the context of chronic inflammatory autoimmune disease. Here we discuss the pharmacology and established uses of statins and in this context describe potential anti-inflammatory and immune-modulatory effects. An extensive in vitro data set defines roles...
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Experimental Evidence for a Role of Dyslipidemia in Renal Injury and for a Renal Protective Effect of Statins T he presence of lipids in renal cells upregulates intracellular signaling pathways involved in inflammatory and fibrogenic responses, both of which are components of progressive renal injury. Lipids activate various growth factors that cause mesangial cell proliferation. Mesangial cell...
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Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan Division of Endocrinology and Metabolism, Department of Internal Medicine, Jichi Medical School, Tochigi 329-0498, Japan Diabetes Center, Tokyo Women's Medical University School of Medicine, Tokyo 1620054, Japan Metabolism, Endocrinology and Atherosclerosis, Institute of Clinical Medicine, Universi...
متن کاملPleiotropic effects of the HMG-CoA reductase inhibitors
The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These secondary actions are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropy of statins and emphasizes the importance of randomized placebo-controlled trials to furth...
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ژورنال
عنوان ژورنال: BMC Microbiology
سال: 2014
ISSN: 1471-2180
DOI: 10.1186/1471-2180-14-93